A New Family of Deamination Repair Enzymes in the Uracil DNA Glycosylase Superfamily
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چکیده
A New Family of Deamination Repair Enzymes in the Uracil DNA Glycosylase Superfamily Hyun-Wook Lee1, Brian N. Dominy2 and Weiguo Cao1,* From 1Department of Genetics and Biochemistry, South Carolina Experiment Station, Clemson University, Room 219 Biosystems Research Complex, 51 New Cherry Street, Clemson, SC 29634, USA 2Department of Chemistry, Clemson University, 100 Hunter Hall, Clemson, SC 29634, USA * Corresponding Author: email: [email protected]; Tel.: (864) 656-4176; Fax: (864) 656-0393. Running Title: A new family of hypoxanthine DNA glycosylases
منابع مشابه
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Uracil-DNA glycosylase (UDG) is a ubiquitous enzyme found in eukaryotes and prokaryotes [1][2][3]. This enzyme removes uracil bases that are present in DNA as a result of either deamination of cytosine or misincorporation of dUMP instead of dTMP [4] [5], and it is the primary activity in the DNA base excision repair pathway. Although UDG activities have been shown to be present in several therm...
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Uracil DNA glycosylases (UDGs) are an important group of DNA repair enzymes, which pioneer the base excision repair pathway by recognizing and excising uracil from DNA. Based on two short conserved sequences (motifs A and B), UDGs have been classified into six families. Here we report a novel UDG, UdgX, from Mycobacterium smegmatis and other organisms. UdgX specifically recognizes uracil in DNA...
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تاریخ انتشار 2011